A total of 150 patients were studied under controlled trial, all suffering from Down's syndrome. Their ages ranged from 3 to 10 yrs. All of these were transfused with 20 million neural stem cells. IV Solumedrol was used as post neural stem cell booster. Significant improvement in cognition was noticed during first month post stem cell which included improvement in understanding and speech. IV Solumedrol was given for 3 days and repeated every 30 days till 6 months. The improvements continued for 6 months and maximum betterment was achieved by the end of 6 months.
Organ specific regenerative neural cells modified from pleuripotent hemopoeitic umbilical cord stem cells are useful for cognitive improvement in Down's Syndrome if employed well with Speech therapy. Moreover, Methyl Prednisone is a potent post neural stem cell booster.